Tuesday, April 30, 2019

What Is a Hypertensive Crisis?




A board-certified physician who oversees a private practice in South Florida, Naval Parikh, MD, also coordinates clinical trials at NAPA Research. With experience as an emergency medical technician, Naval Parikh, MD, has assisted in emergency first-responder situations in connection with 911 calls. 

One common emergency situation involves a hypertensive crisis and is characterized by severely elevated blood pressure, with the diastolic pressure reading exceeding 120 mm Hg. The result of this type of hypertensive emergency is damage to organs such as heart, eyes, brain, blood vessels, and kidneys. Symptoms include visual and neurological disturbances, chest pain, vomiting, and shortness of breath.

In this situation, medical professionals need to lower the patient's blood pressure immediately or acute, progressive damage can further impact the target organs and cause life-threatening conditions such as intracerebral hemorrhage, hypertensive encephalopathy, and acute myocardial infarction.

Among the first-line medical therapies employed in this situation is the adrenergic receptor blocker labetalol, which is administered intravenously. The effect of the drug is to cause vasodilation, while not compromising blood flow in the cerebrum. Alternatively, the vasodilators nitroglycerin and nitroprusside may be used in a hypertensive emergency to decrease blood pressure.

Wednesday, April 24, 2019

Research Shows Folic Acid May Help Ease Depression




A board-certified physician in private practice in Boca Raton, Florida, Naval Parikh, MD, also serves as the clinical site coordinator for NAPA Research. A frequent presenter to physician groups, Naval Parikh, MD, has published articles in peer-reviewed journals on topics such as the relationship between folate supplementation and depression. 

While many people associate folic acid intake with pregnancy, research shows that folate is a critical vitamin throughout life. Folic acid is needed to produce DNA and RNA, and it also serves as an essential component of neurotransmitters, which enable messages to be communicated through different parts of the brain. 

People who are deficient in folic acid generally have low levels of S-adenosylmethionine (SAMe), which is associated with depressive symptoms. A recent review of 11 studies that included 15,315 people revealed that low folic acid levels were linked with depression. This finding has led researchers to believe that increasing folic acid intake will trigger an increase in SAMe, which may lead to a reduction in depressive symptoms. 

However, depression is a complicated illness that generally requires more than one treatment. Those who think they are experiencing depression should seek medical advice and therapy in addition to considering an increase in folic acid intake.

Monday, April 15, 2019

Socio-Demographic Risk Factors For Hypertension


Naval Parikh, MD, coordinates clinical trials at NAPA Research and treats patients as a physician in private practice in Florida. As a former research assistant with the department of social psychology at the University of South Carolina, Naval Parikh, MD, participated in a project focused on hypertension and its social indices.

A 2014 study by MedUni Vienna researchers on the latter topic revealed close links between socio-demographic status and high blood pressure. Impacting women more than men, risk factors include profession, education level, income, and immigrant background. 

According to the report, one of the major risks associated with lower socio-economic status centers on gratification crisis. This involves the person making his or her best effort but not receiving adequate compensation in areas such as job security and opportunities, social recognition, and influence. 

At the same time, higher income allows people to more easily make lifestyle choices, and access better health screening, leading to healthier outcomes and reducing insurance burdens. Lower social status can itself be an outcome of poor health, which points to complex two-way causalities in this area. 

Within the scope of the study, hypertension was significantly higher in eastern Austria than in western Austria. With 19.4 percent of women and 16.6 percent of men in western Austria reporting hypertension, the figure rose to 25.5 percent and 20.1 percent respectively in eastern Austria.

Monday, April 8, 2019

An Introduction to Good and Bad Cholesterol


Florida-based internist Naval Parikh received his MD from the Medical University of South Carolina. As an internal medicine physician at SortinoMD in Boca Raton, Dr. Naval Parikh treats patients for conditions including high cholesterol.

A waxy substance, cholesterol is created by the liver from fat consumed through a person’s diet. It circulates in the blood and bonds to lipoproteins, which carry cholesterol between cells in the body. Lipoproteins are made up of protein on the outside and fat on the inside. 

There are two main types of lipoproteins that carry cholesterol through the body: high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). Each carries cholesterol to a different part of the body, which determines whether the cholesterol is “good” or “bad.”

HDL, which leads to good cholesterol, carries cholesterol back to the liver. Once at the liver, the cholesterol is reprocessed and flushed out of the body. When a person has high levels of HDL, he or she has a lower risk of stroke and heart attack. This is because HDL removes excess cholesterol from the body so that it does not build up in the arteries.

Meanwhile, LDL, responsible for bad cholesterol, carries cholesterol to the arteries. Cholesterol in the arteries often builds up and causes atherosclerosis, a condition that increases the risk of peripheral artery disease, stroke, and heart attack. It may also deprive certain arteries and organs of the oxygen they need to properly function.

Most people have higher levels of LDL in the blood than HDL, the latter of which only accounts for about one-fourth to one-third of total cholesterol levels. On average, women and men should strive for HDL numbers of at least 55 mg/dL (milligrams per deciliter of blood) and 45 mg/dL, respectively. 

Meanwhile, LDL numbers should be as low as possible--no higher than 130 mg/dL in people without blood vessel disease, diabetes, or heart disease. LDL numbers should remain below 100 mg/dL for people who do have these conditions.

Friday, April 5, 2019

ew Research Identifies Premature Brain Stem Cell Aging in MS Patients


Naval Parikh, MD, is a respected presence in the South Florida medical sphere who facilitates clinical trials at NAPA Research. Possessing a background in emergency medicine, Naval Parikh, MD, stays current on developments in the broader health care field. 

A recent UConn Health study published in the Proceedings of the National Academy of Sciences brought focus to findings on the premature aging of brain stem cells among people living with the most severe types of multiple sclerosis (MS). 

As MS advances it impacts the ability of nerves to transmit consistent signals throughout the body, which results in challenges in completing basic tasks such as holding a pen or walking. The major issue is degenerated and inflamed myelin, which acts as insulation around the nerves. The good news is that long periods of remission often occur among those with MS, which allows ample opportunity for recovery.

The periods of relative wellness would be an optimal time for targeted therapeutics focused on prematurely old brain stem cells among progressive MS patients, which act differently than normal brain cells. Understanding them provides important pathways for new treatments that address the underlying neurological deterioration involved in MS.